Mehrdad Sheikhvatan

Diligent position in medical genetics training, research and practice with strong academic background in higher education. Proven track record of developing and delivering engaging course and research materials that enhance student learning and research on clinical and molecular researches. Demonstrated effective communication and research skills that contribute to academic excellence.

Designing and implementing national and international projects in the clinical and genetic fields, leading to the publication of 148 scientific articles and obtaining an H index of 25 and more than 2000 citations.

• Cardiovascular Research Cemter, Istanbul Okan University, Istanbul, Turkey
• Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
• Department of Genetics, Heidelberg University, Heidelberg, Germany

• Demir H, Altuğ Tunçer M, Sheikhvatan M, Abuqalben SM. rs17576 Polymorphism of Matrix Metalloproteinase-9 in Predicting Coronary Artery Disease Severity and Its Adverse Outcome. Genes. 2025;16.
• Demir H, Altuğ Tunçer M, Sheikhvatan M. The value of miR-155 expression in predicting early and long-term outcome of coronary artery bypass grafting surgery. Indian J Thoracic Cardiovas Surg. 2025 (In Press)
• Bahadori AR, Javadnia P, Davari A, Shafiee S, Ranji S, Sheikhvatan M, Tafakhori A. Effect of deep brain stimulation on the severity of seizures and the quality of life in patients with multifocal drug-resistant epilepsy in Iran: A pilot review of local experience. Epilepsy Behav Rep. 2025 Jan 19;29:100742.
• Javadnia P, Bahadori AR, Naghavi E, Imeni Kashan A, Davari A, Sheikhvatan M, Tafakhori A, Shafiee S, Ranji S. Comparative efficacy and safety of therapeutic strategies for mirror aneurysms: A systematic review and meta-analysis. Neurosurg Rev. 2024 Dec 12;47(1):900.
• Nasergivehchi S, Togha M, Jafari E, Sheikhvatan M, Shahamati D. Headache following vaccination against COVID-19 among healthcare workers with a history of COVID-19 infection: a cross-sectional study in Iran with a meta-analytic review of the literature. Head Face Med. 2023 May 19;19(1):19
• Sheikhvatan M, Tuncer MA, Arslan H. Bioinformatic-based study on genes and microRNAs predisposing Covid-19-related cardiovascular injuries. Anatol J Cardiol 2022; 26 (Suppl 1): S1-S177
• Tuncer MA, Sadeghian H, Sheikhvatan M, Toulany M. Causality Association Between COVID-19 Infection and Aortic Dissection. Anatol J Cardiol. 2022 Apr;26(4):338-339.
• Kafan S, Tadbir Vajargah K, Sheikhvatan M, Tabrizi G, Salimzadeh A, Montazer M, Majidi F, Maghuli N, Pazoki M. Predicting Risk Score for Mechanical Ventilation in Hospitalized Adult Patients Suffering from COVID-19. Anesthesiol and Pain Med 2021;11(2):e112424.
• Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S, Cheraghee S. Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease. Iran J Biotech 17 March 2019;17(2):e1921
• Radfar M, Ashrafi MM, Sheikhvatan M, Sadeghian A, Sadeghian H. Determining the Changes in Value of Segmental Longitudinal Strain and Global Longitudinal Strain in Discriminating Left Anterior Descending Artery Involvement: SLS and GLS Changes in Discriminating LADA Involvement. IIMMIN 2019;4(2) 1- 7
• Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S. Association of R279Q and C1562T polymorphisms of matrix metalloproteinase 9 gene and increased risk for myocardial infarction in patients with premature coronary artery disease. J Clin Lab Anal. 2018 Jan;32(1).
• Sheikhvatan M, Ataei Z, Heydari A, Zahergivar A. The value of N-terminal pro-B-type natriuretic peptide (NT Pro-BNP) to predict sudden cardiac death in chronic heart failure patients with normal renal function; a systematic review and meta-analysis. J Nephropharmacol. 2018; 7(2): 164–168.
• Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S. C1019T Polymorphism in the Connexin 37 Gene and Myocardial Infarction Risk in Premature Coronary Artery Disease. The Journal of Tehran University Heart Center 2. 2017(12):72-81.
• Tahouri T, Nazari S, Sheikhvatan M. Thromboembolism due to nephrotic syndrome among children; a systematic review and meta-analysis. J Renal Endocrinol. 2018;4(1): e17.
• Haji Zeinali AM, Marzban M, Zafarghandi M, Shirzad M, Shirani S, Mahmoodian R, Sheikhvatan M, Lotfi-Tokaldany M. Endovascular Aortic Aneurysm and Dissection Repair (EVAR) in Iran: Descriptive Midterm Follow-up Results. Iran J Radiol. 2016 Jan 21;13(1):e16021.
• Najafi M, Sheikhvatan M, Mortazavi SH. Do preoperative pulmonary function indices predict morbidity after coronary artery bypass surgery? Ann Card Anaesth. 2015 Jul- Sep;18(3):293-8.
• Yousefzadeh G, Sheikhvatan M. Age and gender differences in the clustering of metabolic syndrome combinations: A prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS). Diabetes Metab Syndr. 2015 Oct-Dec;9(4):337-42.
• Najafi M, Sheikhvatan M, Sheikhfathollahi M. Discriminative Power of EuroSCORE in Predicting Morbidity and Prolonged Hospital Stay in an Iranian Sample Population. J Tehran Heart Cent. 2014 Jan 12;9(1):15-9.
• Davoodi S, Karimi A, Ahmadi SH, Marzban M, Movahhedi N, Abbasi K, Omran AS, Shirzad M,Sheikhvatan M, Abbasi SH, Bina P. Early outcome of off- pump versus on-pump coronary revascularization. Pan Afr Med J. 2014 Apr 22;17:309.
• Ziaee S., Kalayinia, S., Boroumand, M.A., Pourgholi, L., Cheraghi, S., Anvari, M.S., and Sheikhvatan, M. (2014): Association between the atrial natriuretic peptide rs5065 gene polymorphism and the presence and severity of coronary artery disease in an Iranian population. Coron Artery Dis 25, 242-246.
• Najafi M, and Sheikhvatan, M. (2013): Gender differences in coronary artery disease: correlational study on dietary pattern and known cardiovascular risk factors. Int Cardiovasc Res J 7, 124-129.
• Cheraghi, S., Shajiee, S., Boroumand, M.A., Pourgholi, L., Ziaee, S., Anvari, M.S., Jalali, A., Davoodi, G., and Sheikhvatan, M. (2013): Association between R353Q polymorphism for coagulative factor VII and severity of coronary artery disease in Iranian population. Cardiol J 20, 533-538.
• Najafi, M., Sheikhvatan, M., Montazeri, A., and Sheikhfathollahi , M. (2013): Factor Structure of the World Health Organization's Quality of Life Questionnaire-BREF in Patients with Coronary Artery Disease. Int J Prev Med 4, 1052-1058.
• Nough, H., Eghbal, F., Soltani ,M., Najafi, F., Falahzadeh, H., Fazel, H., and Sheikhvatan, M. (2013): Incidence and Main Determinants of Contrast-Induced Nephropathy following Coronary Angiography or Subsequent Balloon Angioplasty. Cardiorenal Med 3, 128-135.
• Rashidinejad, H., Hosseini, S.M., Moazenzadeh, M., Azimzadeh, B.S., Mirzaeipour, F., Fakhreddini, K., and Sheikhvatan, M. (2012): Relationship between serum level of high-sensitive C-reactive protein and extension of myocardial involvement in patients with acute myocardial infarction. Rom J Intern Med 50, 211-215.
• Yousefzadeh, G., Masoomi, M., Emadzadeh, A., Shahesmaeili, A., and Sheikhvatan, M. (2012): The association of insulin-like growth factor-1 with severity of coronary artery disease.J Cardiovasc Med (Hagerstown). 2012 Nov 15.
• Nough, H., Jorat, M.V., Varasteravan, H.R., Ahmadieh, M.H., Tavakkolian, N., and Sheikhvatan, M. (2012): The value of ST-segment elevation in lead aVR for predicting left main coronary artery lesion in patients suspected of acute coronary syndrome. Rom J Intern Med 50, 159-164.
• Masoomi, M., Samadi, S., and Sheikhvatan, M. (2012): Thrombolytic effect of streptokinase infusion assessed by ST-segment resolution between diabetic and non-diabetic myocardial infarction patients. Cardiol J 19, 168- 173.
• Davoodi, S., Sheikhvatan, M., Karimi, A., Ahmadi, S.H., Goodarzynejad, H., and Fathollahi, M.S. (2012): Outcomes and long-term quality of life of patients with severe left ventricular dysfunction who underwent coronary artery bypass surgery. Gen Thorac Cardiovasc Surg 2012 60, 202-212.
• Najafi, M., Sheikhvatan, M., and Montazeri, A. (2012): Blood glucose concentrations after cardiac surgery: the impact of preoperative quality of life. Int J Diabetes Dev Ctries 32, 93-97.
• Najafi, M., Sheikhvatan, M., and Montazeri, A. (2012): Factor Structure of the World Health Organization's Quality of Life Questionnaire- BREF (WHOQOL-BREF) in Patients with Coronary Artery Disease. Int J Prev Med 4, In Press.
• Najafi, M., and Sheikhvatan, M. (2012): Plausible impact of dietary habits on reduced blood sugar in diabetic opium addicts with coronary artery disease. Int Cardiovasc Res J 6, 375-378.
• Yaminisharif, A., Davoodi, G., Kazemisaeid, A., Sadeghian, S., Farahani, A.V., Yazdanifard, P., Sheikhvatan, M., and Shafiee, A. (2012): Characterization of suitability of coronary venous anatomy for targeting left ventricular lead placement in patients undergoing cardiac resynchronization therapy. J Tehran Heart Cent 7, 10-14.
• Yousefzadeh, G., Hojat, H., Enhesari, A., Shokoohi, M., Eftekhari, N., and Sheikhvatan, M. (2012): Increased carotid artery intima-media thickness in pregnant women with gestational diabetes mellitus. J Tehran Heart Cent 2012 7:156-159.
• Zoroufian, A., Taherian, A., Hosseini, S.K., Sardari, A., and Sheikhvatan, M. (2012): Effects of cardiac rehabilitation program on right ventricular function after coronary artery bypass graft surgery. J Tehran Heart Cent 7, 25- 29.
• Najafi, M., and Sheikhvatan, M. (2012): Does analgesic effect of opium hamper the adverse effects of severe coronary artery disease on quality of life in addicted patients? Anesth Pain 2, 22-27.
• Kazemisaeid, A., Davoodi, G., Yamini Sharif, A., Sadeghian, S., and Sheikhvatan, M. (2011): Cardiac resynchronization therapy during rest and exercise: comparison of two optimization assessed by automated intracardiac electrogram (IEGM) method. Europace 13, doi: 10.1093/europace/eur222.
• Masoomi, M., Zare J., Nasri H., Mirzazadeh, A., and Sheikhvatan, M. (2011): Abrupt opium discontinuation has no significant triggering effect on acute myocardial infarction. J Cardiovasc Med (Hagerstown) 12, 234-238.
• Nasri, H., Mayel, Y., Sheikhvatan, M., and Forood, A. (2011): Premature menopause and severity of coronary artery disease. J Res Med Sci 16, 1026- 1031.
• Mahmoodzadeh, S., Moazenzadeh, M., Rashidinejad, H., and Sheikhvatan, M. (2011): Diagnostic performance of electrocardiography in the assessment of significant coronary artery disease and its anatomical size in comparison with coronary angiography. J Res Med Sci 16, 750-755.
• Hakki Kazazi, E., Sheikhvatan, M., Mahmoodian, M., Sheikh Fathollahi, M., and Sadeghian, H. (2011): Comparing angiography features of inferior versus anterior myocardial infarction regarding severity and extension in a cohort of Iranian patients. JRMS 16, 484-489.
• Kazemisaeid, A., Bozorgi, A., Yamini Sharif, A., Davoodi, GH., Sadeghian, S., Sadeghian, H., Dogmehchi, E., and Sheikhvatan, M. (2011): Predictive Power of the Baseline QRS Complex Duration for Clinical Response to Cardiac Resynchronisation Therapy. Eur J Cardiovasc Med 1, 52-56.
• Nejatian, M., Zarghampour, M., Karimi, A., and Sheikhvatan, M. (2011): The Benefit of a Cardiac Rehabilitation Programme on Cardiovascular and Exercise Parameters in Patients with Type 2 Diabetes Mellitus: The First Study Among the Iranian Population. Eur J Cardiovasc Med, 1, 39-45.
• Azimzadeh, M., Moazenzadeh, M., Narouei, S., Zare, J., and Sheikhvatan, M. (2010): Diastolic Heart Failure in Patients with Slow Coronary Flow. Euro J Cardiovasc Med 1
• Moazenzadeh, M., Azimzadeh, B.S., Zare, J., Shokouhi, M., and Sheikhvatan, M. (2010) Clinical Features and Main Determinants of Coronary Slow Flow Phenomenon in Iranian Patients. Euro J Cardiovasc Med 1.
• Davoodi, S., Sheikhvatan, M., Karimi, A., Ahmadi, A., and Sheikhfathollahi, M. (2010): Determinants of Social Activity and Work Status after Coronary Bypass Surgery. Asian Cardiovasc Thorac Ann 18, 551-556.
• Davoodi, G., Yamini Sharif, A., Kazemisaeid, A., Sadeghian, S., Vasheghani Farahani, A., Sheikhvatan, M., and Pashang, M. (2010): Comparison of heart rate variability and cardiac arrhythmias in polluted and clean air episodes in healthy individuals. Environ Health Prev Med 15, 1-7.
• Narooei, S., Sarvar Azimzadeh, B., Zare, J., Rashidinejad, H., Sheikhvatan, M. (2010): Diagnostic performance of the post-exercise systolic blood pressure response for the detection of severe coronary artery disease. KMJ 42, 217-221.
• Najafi, M., Sheikhvatan, M., Ataie-Jafari A. (2010): Different effects of opium use in coronary artery disease patients in Iran. Subst Use Misuse 45, 2579-2581.
• Masoomi, M., Zare, J., Kahnooj, M., Mirzazadeh, A., Sheikhvatan, M. (2010): Sex differences in potential daily triggers of the onset of acute myocardial infarction: a case-crossover analysis among an Iranian population. J Cardiothoracic Vasc Anesth 22, 11.
• Sheikhvatan, M., Nejatian, M., Sardari, A. (2010): Baseline Systolic Blood Pressure Response to Exercise Stress Test Can Predict Exercise Indices following Cardiac Rehabilitation Program. J Teh Univ Heart Ctr 4: 184-187.
• Yamini Sharif, A., Davoodi, G., Vasheghani Farahani, A., Fadavi, H., Kazemi Saeed, A., Sadeghian, S., Ghazachai, F., Sheikhvatan, M. (2010): Ablation of focal right upper pulmonary vein tachycardia using retrograde aortic approach. J Teh Univ Heart Ctr 3, 146-149.
• Najafi, M., Sheikhvatan, M., and Sheikhfathollahi, M. (2009): Factor analysis of World Health Organization's Quality of Life-BREF health survey questionnaire in patients with coronary artery disease. J cardiothoracic vascular anesthesia 23, 31.
• Najafi, M., Sheikhvatan, M., and Sheikhfathollahi, M. (2009): Serum C-reactive protein and adherence to the Mediterranean diet in the patient with coronary artery disease. J Cardiothoracic vasc anesth, 23, 40.
• Najafi, M., Sheikhvatan, M., and Montazeri, A. (2009): Quality of life-associated factors among patients undergoing coronary artery bypass surgery as measured using the WHOQOL-BREF. Cardiovasc J Afr 20, 284-289.
• Davoodi, S., Karimi, A., Ahmadi, S.H., Marzban, M., Movahhedi, N., Abbasi, K., Omran, A.S., Shirzad, M., and Sheikhvatan, M. (2009): Short- and mid-term results of triple-valve surgery with an evaluation of postoperative quality of life. Tex Heart Inst J 36, 125-130.
• Najafi, M., Sheikhvatan, M., Montazeri, A., and Sheikhfathollahi, M. (2009): Reliability of World Health Organization's Quality of Life-BREF versus Short Form 36 Health Survey questionnaires for assessment of quality of life in patients with coronary artery disease. J Cardiovasc Med (Hagerstown) 10, 316-321. [
• Najafi, M., Sheikhvatan, M., Montazeri, A., and Sheikhfathollahi, M. (2009): Quality of life in opium-addicted patients with coronary artery disease as measured with WHOQOL-BREF. Int J Soc Psychiatry 55, 247-256.
• Aramin, H., Sheikhvatan, M., and Sheik Fathollahi, M. (2009): Can Preoperative Quality of Life Predict Adverse Outcome of Coronary Artery Bypass Surgery in the Elderly? Middle East J age aging 6, 6-10.
• Soleimani, A., Salehi Omran, A., Haji Zeinali, A.M., Sheikhvatan, M., and Feyzi, I. (2009): Return to work following cardiac rehabilitation in patients undergoing cardiac procedures with an approach to patient’s viewpoints and attitude. KMJ, 41.
• Sadeghian, H., Sheikhvatan, M., Mahmoodian, M., Sheikhfathollahi, M., Hakki, E., Sadeghian, A., Behnam, B., Haji Zeinali, A.M., and Semnani, V. (2009): Comparison of Short-Term Clinical Outcome of Non-ST Elevation versus ST Elevation Myocardial Infarction. J Teh Univ Heart Ctr, 4, 97-102.
• Sheikhvatan, M., Abbasi, A., Goodarzinejad, H., Darrehzereshki, A., and Sheikh Fathollahi M. (2008): An Echocardiographic study of heart in a group of adult elite Athletes. Heart Surg Forum 11, 168.
• Sheikhvatan, M., Davoodi, S., Abbasi, A., Goodarzynejad, H., Sheikh Fathollahi, M. (2008): The impact of coronary artery disease on early outcome of Aortic valve replacement in elderly patients. Turk Kardiyol Dern Ars 36, 152.
• Sheikhvatan M. (2008): Segmental backflow phenomenon without diagnostic criteria of coronary aneurism or ectasia. Turk Kardiyol Dern Ars 36, 102.
• Najafi M., Sheikhvatan, M., Montazeri, A., and Sheikhfathollahi, M. (2008): Predictors of quality of life among patients undergoing coronary artery bypass surgery. Acta Cardiol 63, 713-721.
• Najafi, M., Sheikhvatan, M., Montazeri, A., and Abbasi, H. (2008): Quality of life in coronary artery disease: The SF-36 compared to the WHOQOL-BREF. J Cardiothoracic Vasc Anesth 22, 11.
• Montazeri, A., Najafi, M., Sheikhfathollahi, M., and Sheikhvatan, M. (2008): Is WHOQOL-BREF questionnaire a reliable and valid tool for the assessment of quality of life in patients with coronary artery disease? Anesth Analg 106, 126.
• Davoodi, S., Karimi, A., Ahmadi, S.H., Marzban, M., Movahhedi, N., Abbasi K., Omran, A.S., Shirzad, M., Sheikhvatan, M., and Abbasi SH. (2008): Coronary artery bypass grafting in patients with low ejection fraction: the effect of intra-aortic balloon pump insertion on early outcome. Indian J Med Sci 62, 314-322.
• Nejati, V., Shirinbayan, P., Akbari Kamrani, A., Foroughan, M., Taheri, P., and Sheikhvatan, M. (2008): Quality of life in elderly people in Kashan, Iran. Middle East J age aging 5, 21-25.
• Karimi, A., Ahmadi, S.H., Davoodi, S., Sheikhvatan, M., and Abbasi, S.H. (2008): Early outcome of concurrent mitral valve replacement and coronary artery bypass grafting. Acta Medica Iranica, 46, 213-217.
• Sadeghian, S., Sheikhvatan, M., Hakki Kazazi, E., Roozkari, M., and Sheikhfathollahi, M. (2008): Predictive value of stress test in comparison with perfusion scans in different age groups on the basis of angiography reports. TUMJ 65, 36-40.
• Nozari, Y., Hashemlu, A., Hatmi, Z.N., Sheikhvatan, M., Iravani, A., Bazdar, A., Babakhan, N., and Ghasri, N.G. (2007): Outcome of coronary artery bypass grafting in patients without major risk factors and patients with at least one major risk factor for coronary artery disease. Indian J Med Sci 61, 547-554.
• Karimi, A., Ahmadi, S.H., Davoodi, S., Sheikhvatan, M., and Abbasi, S.H. (2007): Early outcome of coronary artery bypass surgery in patients less than 40 years old comparing with elderly patients. J Teh Univ Heart Ctr 2, 95-99.
• Davoodi, S., Karimi, A., Ahmadi, S.H., Sheikhvatan, M., and Abbasi, S.H. (2007): Early outcome of coronary artery bypass grafting in patients with severe left ventricular dysfunction. J Teh Univ Heart Ctr 2, 167-172.

Certified Research Manager, Cardiovascular Surgery Research Center, Istanbul Okan University, Turkey (2018-2025)

Certified Research Manager, Sina Hospital, Tehran, Iran (2010-2017)

Alexander von Humboldt Research Fellowship, Heidelberg University, Germany (2008-2009)

Licensed Research Manager, Cardiac Surgery Department, Tehran Heart Center, Iran (2005 to 2008)